Dr. Nase,

As Chris pointed out in an earlier post, most laymen do not understand the research that goes into hypotheses and treatment predictions that you must make.... usually 5 to 7 years in advance. Could you comment on major rosacea treatment predictions that are finally coming to fruition:

1. Oral Ivermectin for treatment resisitant papules and pustules

2. G-protein response modifiers that you predicted would be available for neutrophil treatment and rosacea redness treatment 7 years in advance.

3. Pre-flushing for better laser treatment - now picked up by a pharmaceutical company

4. Post-laser treatment constrition and oxygen therapy - now picked up by a pharmaceutical company

5. Topical Phenylephrine that you and Dr. Bitter Sr. patented

6. Pre-moistening the skin with mineral water for better laser treatment

7. Hypothalamic treatment targets for rosacea flushing and blushing

Isn't it funny how the Pascoe's and Cloutier's of this world won't revise their mistakes and give you the credit your due. My word, Artist actually has her photo on an Eidermal Growth Factor that you publushed about on the rosacea forum in 2004. Now they offer wonderful day spa treatments under Volcanic ash and don't have the foggiest idea that 35% of all medical journal articles are wrong.... like the one where they recommend cutting off the rhinophyma red nose without truly knowing that these noses will become deformed, have huge gashes in them, the pores will become 500% larger, their noses are chronically red, and the regrowth of the nose starts the following day after treatment. They blindly believe journal articles. Extremely misleading and dangerous. My word, Pascoe even wrote an article on taking oral nitric oxide inhibitors because you can get them from Sigma Chemicals. This treatment would result in death from stroke and heart attacks.

You consulted me away from this disfiguring treatment that often results in skin flaps being taken from the buttocks! Low dose, long terh accutane shrunk my nose back to normal size like yours, reduced the redness and swelling, shrank the pores by over 80% and was a true Godsend.

Duke,

Good catch. As you know I have been following G-Protein Response Modifiers for rosacea for nearly 7 years and have been involved in preliminary G-Protein testing for vascular hyper-responsiveness, uncontrolled vascular growth and vasculopathy. G-Proteins are one of the backbone treatment fields for Physiologists. They are also the key to rosacea remission... not a cure... but remission.

You can't block the hundreds of dilators and inflammatory substances in the skin, but you can block one specific "G-Protein Subunit" from binding onto hundreds of receptors and effectively blocking the entire signal transduction cascade from ever occuring. This means that if a dilator substance (a key) binds onto a receptor (a lock), a g-protein must couple to the "key" and "lock" to allow further action. If the g-protein cannot couple with these two, then nothing happens.... the cells are never told to dilate OR inflammatory cells are never told to be produced OR DNA is never told to be replicated into damaging enzymes, etc. This is selective targetting without side effect.


There is now a G-Protein response modifier available oversees that blocks neutrophil mediated inflammation (they are using it just for cosmetics and anti-aging) but it is much more than this as rosacea is a neutrophil-based disorder. We can use this product right now and I would predict that it would be the most effective anti-rosacea topical to date, bar none.

Plus, this same company is developing specific rosacea treatments. This is the way to go and the best way to attack rosacea. Block one G-protein to block one hundred inflammatory pathways. It's what they call "smart" medicine.

I am completing an interview with several companies currently researching and developing oral and topical g-protein inhibitor drugs for inflammatory dermatoses and rosacea... let me complete my interviews and put a report together as this important subject deserves more than a posting.

__________________
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Best,
Geoffrey

Dr. Geoffrey Nase
Ph.D: Neuro-Vascular Physiologist

Email: drnase1000@hotmail.com
Bibliography: http://drnase.com

All posts are for informational purposes only. Please visit our Home Page to view our Medical Disclaimer.

What is the product? Can we get it here in the U.S.?

Hi Dan,

I am following up on both G-protein products. It looks like US researchers and doctors will be able to get samples from the UK and Japan.

Signum Biosciences is developing a new product based on G-protein Response Modulation. Their first product, for anti-aging, called Arazine will be available in two to four months and they are currently working on a second generation of products to target inflammatory skin disorders such as rosacea, psoriasis and eczema.

What they don't realize yet is that Arazine is an excellent treatment choice for rosacea due to its anti-inflammatory actions in the skin and its affect on damaging neutrophils. It is more than an anti-aging product. We can use this right now!

Information from their Website - Soon to be followed up with indepth interviews on their current product and their second generation rosacea product:


According to Signum Bioscience’s Development Pipeline, SIG990 is in the preclinical phase as a rosacea treatment.

G-protein Response Modulators

Signum Bioscience’s patented compounds and methods revolve around a group of derivatives called prenyl peptides. Signum’s GPM Technology Platform constitutes a new class of non-steroidal anti-inflammatories that have broad utility over multiple therapeutic areas by acting as G-protein modulators (GPMs). Initially anti-aging and anti-inflammatory compounds will have immediate impact in skin care products as topical cosmeceuticals (e.g. Arazine™) followed by pharmaceutical inflammatory skin applications. Furthermore, Signum’s goal is the development of anti-inflammatory pharmaceuticals.



GPM Pharmaceutical Development

The most common topical treatment options include antimicrobial agents (e.g. Metrogel, Clindamycin, Clindamycin-Benzoyl peroxide, Sodium Sulfacetamide/Sulfur and Finacea) which inhibit ROS generation by neutrophils, thereby reducing inflammation. However, these treatments do not reduce the initiating inflammatory events (inflammatory mediator release and neutrophil recruitment) of rosacea.

Conversely, GPMs inhibit inflammation directly and indirectly by reducing activity and/or expression of all the key players in rosacea, not just ROS production

Results demonstrate that GPMs:

•Inhibit release of key inflammatory mediators (e.g. TNF-α, IL-6, IL-8, VCAM-1, GM-CSF, Gro-α, MCP-1)
•Inhibit neutrophil adhesion and infiltration
•Inhibit ROS production from neutrophils
Given Arazine’s safety and effectiveness as an anti-inflammatory, second generation GPM compounds, provide an effective nonsteroidal alternative for patients suffering from skin diseases such as: rosacea, acne, psoriasis and eczema.

The first GPM based topical containing Arazine is planned to be released to the Japanese market in the second quarter of 2010.

__________________
_

Best,
Geoffrey

Dr. Geoffrey Nase
Ph.D: Neuro-Vascular Physiologist

Email: drnase1000@hotmail.com
Bibliography: http://drnase.com

All posts are for informational purposes only. Please visit our Home Page to view our Medical Disclaimer.

Thanks for the info Dr. Nase. What is the relationship between Cyclic AMP and G Protein? This product: About Strata-C | goodbye-redness.com seems to target inflammation similar to what you are talking about.

Dan,

Their website statements are incorrect. Cyclic AMP is found inside cells and activates calcium channels... it does nothing topically; however, with that said, the overall formulation seems to be quite good.

I know LadyGolf really likes Stata G... give her a holler.

__________________
_

Best,
Geoffrey

Dr. Geoffrey Nase
Ph.D: Neuro-Vascular Physiologist

Email: drnase1000@hotmail.com
Bibliography: http://drnase.com

All posts are for informational purposes only. Please visit our Home Page to view our Medical Disclaimer.

What does preclinical studies mean?

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Doug

Doug,

Preclinical refers to studies done in the laboratory or on humans (in isolated cases). They are anecdotal with no proven clinical application yet. Thus the next stage is the clinical stage where studies are performed on large numbers of human test subjects to determine if the treatment is valid and has a real effect.

Michael

Thank you!

__________________
Doug

So, is there any way to purchase this product from the Japanese Market? Why wait if we don't have to? Sounds like the best topical to date hands down.