Hey Jeff,

Are you going to release your phenylephrine cream?

I understand you are testing 5 concentrations to either develop or sell the rights to Dermik with Dr. Bitter?

I guess its time to give up on SansRosa and allow a vascular specialist to develop a vascular modifying medication?

Good luck. If you need any testers, please contact me.

JD

After several recent discussions this weekend, Dr. Bitter, Sr. MD and I decided to move forward with the phenylephrine topical. This is especially important now that SansRosa has, for all intents and purposes, failed.

They used the wrong constrictor and did not have any vascular specialists collaborating with them to develop this complex topical treatment.

We will keep you posted on our next step, whether it is selling the patent to Dermik and allowing them to move forward, or developing it at our own independent lab....

__________________
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Best,
Geoffrey

Dr. Geoffrey Nase
Ph.D: Neuro-Vascular Physiologist

Email: drnase1000@hotmail.com
Bibliography: http://drnase.com

All posts are for informational purposes only. Please visit our Home Page to view our Medical Disclaimer.

Dr. Nase,

Is that topical similar to the one Susan has?

Hallo Dr. Nase,

I just did a post under the thread Brimonidine Gel (SansRosa) for Rosacea Symptoms, Facial Redness & Facial Flushing in the General Rosacea question section. I asked about the development of the phenylephrine cream. Now I found this information. Great to see things are on their way. Please go on! We need this topical! When do you think will it be available?

May I suggest putting together the General Rosacea Questions and the Dr. Geoffrey Nase - Rosacea Q & A as one section as the threads in both are very similar? It would be easier to check out when having it all in one row (just my opinion of course). I’m sure all threads and questions started in this forum are in the intent to get your appreciated input anyway. You have so much knowledge about rosacea and you also have the corresponding medical knowledge to put things together so rosacea can be understood and treated better.

Best wishes,

Barbara

Thanks for the suggestions Barbara. I will have the Admin make the necessary changes.

We have 15 testers lined up to test a Phenylephrine treatment cream at various concentrations (5%, 7.5% and 10%). We are just working on the stability issues. Once these are ironed out we can start.

Cheers

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__________________
_

Best,
Geoffrey

Dr. Geoffrey Nase
Ph.D: Neuro-Vascular Physiologist

Email: drnase1000@hotmail.com
Bibliography: http://drnase.com

All posts are for informational purposes only. Please visit our Home Page to view our Medical Disclaimer.

Addition of Buffering Compound (Peptide) to Prevent Rebound Dilation

One of the main concerns with any topical constrictor is that patients might experience rebound dilation..... this means that after a short time on the treatment, vessels may actually spontaneously dilate and flush (to a greater extent than prior to treatment). This is where SansRosa has failed. Too much constriction causes lack of oxygen to nearby skin cells -- they in turn release hypoxia factors to cause dilation to make sure the cells have plenty of oxygen.
SansRosa has approached the development of this product from a Dermatologist standpoint from day one..... and thus the failures for 9 straight years.

You must address it from the Vascular side. Vascular Physiologists have been trained to "hold" constriction in the safe zone of 20% to 30% which greatly reduces redness and flushing --AND-- does not induce any degree of rebound. To ensure this process holds steady over months, "Buffers" or peptides can be added to the treatment.

That is what we are experimenting on right now, in addition to a time release base that remains stable.

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__________________
_

Best,
Geoffrey

Dr. Geoffrey Nase
Ph.D: Neuro-Vascular Physiologist

Email: drnase1000@hotmail.com
Bibliography: http://drnase.com

All posts are for informational purposes only. Please visit our Home Page to view our Medical Disclaimer.

Doc,

You still have me signed up as a tester? I have pretty severe redness that reacted positively to the preparation H gel with .5% Phenylephrine, so I think I'd make a good candidate. Too bad the witch hazel in preparation H is terrible for rosacea skin.

You can sign me up for the strong stuff. 10% ought to do it!

Thanks for everything.

Chris

Chris,


Testing is going on right now on topical Phenylephrine. Just contact the Pharmacist in charge, Susan Merenstein and she should be able to guide you through the process.

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It looks like Dr. Nase suggests that we still need an alpha 1 (phenylephrine) and alpha 2 agonist (?) for best long-term results and to prevent any rebound dilation.