Rosacea Knowledge Forum by Geoffrey Nase PhD - View Single Post - Oral and Topical Rambazole Nearing Finish Line

Dr. Geoffrey Nase · #10 (**permalink**) 23rd November 2011, 05:04 AM

Rambazole may be available for Plaque Psoriasis first ... and at the same time allow for "off-label" treatment for rosacea.

Rambazole (talarozole)
BRAND NAME: Rambazole
GENERIC NAME: talarozole
EXPERIMENTAL/INTERNAL COMPANY NAME: R115866
TESTING PHASE II
CLINICAL TRIALS

DRUG USE (P OR PsA) METHOD OF DELIVERY DEVELOPING COMPANY/COMPANIES

Moderate to severe plaque psoriasis Oral Barrier Therapeutics/ Stiefel, a GSK Company

Description and Comments

Rambazole is a retinoic acid metabolism blocking agent (RAMBA), which means that it inhibits the natural biological breakdown of retinoic acid. Retinoic acid (Vitamin A) and related compounds called retinoids (e.g. Soriatane/acetretin) have long been known to be effective treatments for psoriasis. By preventing the breakdown of retinoic acid, drugs like Rambazole increase the amount of retinoic acid inside cells, thereby relieving psoriasis symptoms in a manner similar to Soriatane/acetretin. Studies are underway to determine whether Rambazole can provide the same benefits as Soriatan/acetretin with fewer side effects such as increased lipid levels.

Other News and Links